纽约大学医学院心内科以及Kimmel干细胞生物学中心龙承祖实验室现招聘博士后以及访问学生学者。我们运用基于CRISPR系统的基因编辑技术定点高效修复肌萎缩动物模型以及病人干细胞分化3D心脏组织中引起病变的基因，成功的恢复了肌肉以及心脏的正常功能 [Science345 (6201), 1184-1188；Science328 (5974), 94-98;Science Translational Medicine9 (418), eaan8081;ScienceAdvances3 (4), e1602814;Science Advances4 (1), eaap9004]。我们正进一步结合分子生物学，干细胞技术及蛋白质组学等多种手段将该项研究成果拓展到大型动物疾病模型以及病人的心肌细胞修复等转化医学研究中。该研究也为运用基因编辑技术治疗其他心血管遗传病提供新思路和理论依据[JAMA neurology73 (11), 1349-1355;Physiological Reviews98 (3), 1205-1240]。

博士后应聘者需具有生物，医学等相关专业博士学位，良好的沟通合作精神以及严谨的科研态度。我们将优先考虑有干细胞实验，神经学，小鼠遗传学背景的应聘者。

纽约大学医学院成立于1841年。在最新的U.S. News & World Report排名中位列全美医学院科研第三名。实验室以及医学院将提供具有前瞻性的课题，充足的科研保障，方便的住房安排以及良好的生活福利待遇。实验室坐落在国际大都会纽约城曼哈顿岛东岸，具有良好的文化氛围和活跃的科研合作环境。

应聘者请将简历，个人研究介绍以及三位推荐人联系方式发送至：Chengzu.Long@NYUMC.org（邮件标题注明：应聘岗位+毕业院校+本人姓名+高层次人才网）

Genome Editing to Model and Treat Monogenic Diseases

Two postdoctoral positions are available immediately in the laboratory of Chengzu Long, PhD, at NYU Langone’s Leon H. Charney Division of Cardiology and Helen L. and Martin S.KimmelCenter for Stem Cell Biology. Our projects focus on advancing the novel genome-editing technology to model and treat cardiac and neuromuscular diseases. For more information, see JAMA Neurology 2016.

Monogenic disorders affect millions of people worldwide. The recent advance in novel precision genome-editing technologies and human pluripotent stem cell biology are revolutionizing our approach to study the pathology of diseases and eventually to develop the potential therapeutics for these diseases. Using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system-mediated genome editing, we successfully prevented muscular dystrophy in the mouse model. For more information, see Science 2014 and Science 2016.

We are optimizing genome-editing strategies on the culprit genes in patients’ cardiomyocytes, three-dimensional engineered heart muscle (for more information, see Science Advances 2018)

The ideal candidate holds a PhD and/or MD in biological sciences or biomedical-related fields. Candidates with expertise in stem cell biology and neuroscience are particularly encouraged to apply.

To apply or to obtain more information about this position, please contact Dr. Long atchengzu.long@nyumc.org. Applicants should include a CV, brief statement of research background, and names of three references.

NYU School of Medicine ranked no. 3 in the nation out of 144 medical schools nationwide on the 2018–2019 “Best Graduate Schools” list issued by U.S. News & World Report. NYU School of Medicine is an equal opportunity employer committed to fostering diversity for postdoctoral fellows in the workplace. Our positions offer competitive salaries, excellent benefits, and eligibility for student housing.

特别说明：本单位在招聘过程中不会以任何名义向求职者收取任何费用，请各位求职者在求职过程中提高警惕，谨防受骗。

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