实验室研究方向：

T cells play essential roles in immune response. We are studying T cells with two directions:

1. Functional genomics in primary T cells

We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment.  Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. Mechanisms of metabolic regulation of T cells

Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.

 

近期代表性成果如下：

1. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437. 

2. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484. *equal contribution. 

Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”. 

Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.

Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.

3. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33. 

Highlighted in Nat Rev Mol Cell Biol, 2014; 15: 701, “A RAG dissociation inhibitor”.

 

博士后 招聘1名： 

应聘条件：

1）具有免疫学、分子和细胞生物学相关专业博士学位，获得博士学位1年以内

2）近3年以第一作者身份在国际知名学术期刊发表研究论文，符合清华大学博士后入站标准 

3）热爱科研工作，责任心强，具备团队合作精神 

4）具备较好的英语沟通、阅读和写作能力 

岗位待遇：在清华大学博士后的标准薪酬和待遇基础上，课题组支持博士后申请相应奖学金计划。享受具有竞争力的薪酬资助和优秀的科研环境。具体情况参见清华大学博士后申请相关网页。

申请材料以及申请方式：

1） 个人简历（包括主要学习和研究经历、发表论文列表，参与项目、奖励等）

2） 个人英文陈述（包括详细的个人研究兴趣，主要研究成果和未来的职业规划等）

3） 2-3位推荐人（其中一位应为本人博士导师）的联系方式

4） 申请材料发送至pengmin@tsinghua.edu.cn，主题标明“姓名+应聘博士后+高层次人才网“

提示：以担保或任何理由索要财物，扣押证照，均涉嫌违法。一经发现，立即举报。