Introduction of the Director

Eric Westhof is a member of the French Academy of Sciences and the German Academy of Sciences (Leopoldina), a member of the European Molecular Biology Organization (EMBO), a member of the Association of Chinese and French Experts, a principal researcher at the Wenzhou Institute of the University of the Chinese Academy of Sciences (UCAS), a visiting professor at the Southwest University of China (SWU), a professor emeritus of the University of Strasbourg (UNIS), and the president of the French Society of Gutenberg Representative.

For his outstanding academic achievements, he has received several French and international awards, including the Jacques Monod Prize, the Charles Leopold Meyer Prize, the Distinguished Service Award of the RNA Society, the Fyodor Lynn Medal of the German Society for Biochemistry and Molecular Biology, the Wang Yingjian Medal of the Shanghai Institute of Biochemistry of the Chinese Academy of Sciences, and the Rolf Sammet Prize of the Johann Wolfgang Goethe University in Frankfurt, Datta Medal of the European Union of Biochemistry, and the Lifetime Achievement Award of the International RNA Society.

According to Web of Science, he has published 477 papers (32,760 citations with an h-index of 97), 23 in the Nature series of journals and 11 in Science. He was ranked 685th worldwide and 11th in France in the 2024 Research.com ranking of scientists in biology and biochemistry and received the Leaders in Biology and Biochemistry Award. He is ranked 5th in the field of RNA in the 2022 ScholarGPS Global Highly Ranked Scholars. He has co-edited four books and serves on the editorial boards of several internationally recognized academic journals, including Associate Editor of RNA, Executive Editor of Oxford University Press Nucleic Acids Research, Executive Editor of Wiley Journal of Molecular Recognition, and Executive Editor of Elsevier Biochemistry and Biophysics Research Letters.

Projects and Research

His research activities focus on the relationship between sequence, three-dimensional structure, evolution and function of RNA molecules. The goal is to understand RNA evolution and the ongoing interaction between sequence changes and RNA structure/activity. Through comparative crystallographic and bioinformatics approaches, he studied RNA folding and biological functions. To this end, he introduced the "Leontis-Westhof" RNA base pair nomenclature to annotate all types of base pairs in nucleic acids, and in 2010 he launched RNA-Puzzles, an international competition to evaluate blind predictions of 3D RNA structure. The project is part of an ongoing effort to extract maximum information from structure-anchored comparative sequence analysis. Because sequence alignment and 3D assembly of RNA modules have enabled me to predict large catalytic RNAs, such as those of group I introns and RNaseP, he hopes to continue my research along these lines. Indeed, RNA sequence alignments are extremely rich; they allow the identification of conserved helix lengths, unpaired regions, anchor points, conserved residues, semi-conserved residues, concatenated regions, RNA modules and conserved hairpins, conserved or exchanged non-Watson-Crick pairs, as well as key structural residues (e.g., U-turns). The project will include (1) development of methods and tools for generating structure comparisons, i.e., experimental structure-based comparisons, and (2) automation of the overall process.

Conditions for recruitment

1. Hold PhD in molecular chemistry, molecular biology, structural biology or bioinformatics;

2. Good reading and writing skills in English ;

3. Ability to work independently on a computer, and proficiency in at least one programming language;

4. Skills in molecular calculations or sequence alignments are advantageous.

Compensation

The postdoctoral students will be admitted to the postdoctoral mobile station of University of Chinese Academy of Sciences (UCAS), and the fresh graduates will enjoy the same policies as those of NUST, such as staying in Beijing and working place is in Wenzhou, and the outstanding ones can be recruited as the associate researcher of the subject group after leaving the station. The postdoctoral positions are divided into three categories (A, B and C), and the salaries are as follows:

A: 40W + tutor's allowance (0-18W) + performance incentive + five insurance and one gold.

B: 30W + mentor subsidy (0-12W) + performance incentives + five insurance and one pension

C: Negotiable mentor + performance incentive + five insurance and one gold

Talent apartment can be rented, about 1500RMB/month (Postdoctoral fellows who leave the station and stay to work in Wenzhou can buy 60% discount talent housing)

Application

1. Please send a detailed CV in Chinese or English (photo, birthplace, education and work experience, list of achievements in scientific research with supporting documents, etc.).

2. Send the electronic version of the documents to eric@wiucas.ac.cn ou cl@wiucas.ac.cn

负责人介绍

埃里克·韦斯托夫（EricWesthof）是法国科学院院士，德国科学院院士，欧洲分子生物学组织（EMBO）成员，法国法中高级人才交流协会（AEFC）会员，国科温州研究院首席研究员，西南大学客座教授，斯特拉斯堡大学名誉教授，法国古腾堡（Gutenberg）科学家联盟执行主席。

因其卓越的学术成就，他获得了多个法国和国际奖项，包括雅克·莫诺奖、查尔斯-莱奥波德·迈耶奖、RNA协会杰出服务奖、德国生物化学和分子生物学协会费奥多·林恩奖章、中国科学院上海生物化学研究所王应睐奖、法兰克福约翰·沃尔夫冈·歌德大学罗尔夫·萨梅特奖、欧洲生物化学联合会达塔奖章以及国际RNA学会终身成就奖。
根据WebofScience，他发表了477篇论文（32,760次引用，h指数为97），其中23篇在《自然》系列期刊上，11篇在《科学》上。他在2024年Research.com的生物学和生物化学领域科学家排名中位列全球第685位，法国第11位，并获得生物学和生物化学领域领导者奖。在2022年ScholarGPS全球高排名学者中，他在RNA领域排名第五。他合编了4本书，并担任多个国际知名学术期刊的编辑委员会成员，包括《RNA》科学的副主编、牛津大学出版社《核酸研究》的执行编辑、威利《分子识别杂志》的执行编辑和爱思唯尔《生物化学和生物物理研究通讯》的执行编辑。

项目与研究
他的研究集中在RNA分子的序列、三维结构、进化和功能之间的关系。目标是理解RNA的进化以及序列变化与RNA结构/活性之间的持续互动。通过比较晶体学和生物信息学的方法，他研究了RNA的折叠和生物功能。为此，他引入了“Leontis-Westhof”RNA碱基配对命名法，以注释核酸中的所有类型碱基对，并在2010年发起了RNA-Puzzles，这是一项评估3DRNA结构盲预测的国际竞赛。该项目是从结构锚定的比较序列分析中提取最大信息的持续努力的一部分。因为序列比对和RNA模块的3D组装使他能够预测大型催化RNA，如I组内含子和RNaseP的RNA，他希望沿这些方向继续研究。事实上，RNA序列比对极其丰富；它们允许识别保守的螺旋长度、未配对区域、锚点、保守残基、半保守残基、协变区域、RNA模块和保守发夹、非Watson-Crick配对的保守或交换，以及关键结构残基（如U型转折）。项目将包括（1）开发用于生成结构比对的方法和工具，即基于实验结构的比对；（2）整体过程的自动化。

招聘条件
拥有分子化学、分子生物学、结构生物学或生物信息学的博士学位；

良好的英语阅读和写作能力；
具备良好的独立电脑工作能力，掌握至少一种计算机语言；
具备分子计算或序列比对的能力者优先。
薪酬
博士后：博后入中国科学院大学博士后流动站，应届生享受国科大留京户口等同等政策，工作地点在温州，出站后优秀者可应聘课题组副研究员。博士后分为三类(A类、B类和C类)，薪资如下：

A：40W+导师补贴(0-18W)+绩效奖励+五险一金
B：30W+导师补贴(0-12W)+绩效奖励+五险一金
C：导师面议+绩效奖励+五险一金
可租住人才公寓，约1500元/月左右（博后出站留温工作，可购买6折人才房）
申请
1.请提交中文或英文的详细简历（照片、出生地、教育和工作经历、科研成果清单及支持文件等）。

2.邮件主题命名为:"Name-Postdoctoral fellowship".将电子版文件发送至eric@wiucas.ac.cn或cl@wiucas.ac.cn，邮件主题命名为：“姓名-博士后招聘”

信息来源于网络，如有变更请以原发布者为准。

来源链接：

https://www.wiucas.ac.cn/recruitment/keyan/2024/2009.html

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